​​​​​​​​​​​​The Trusted Source for Preventive / Regenerative ​Medicine

​​​​​​​​​California HealthSpan Institute      


​​​320 Santa Fe Drive, Suite 211

Encinitas, CA 92024




Argarwal PK et al. Testosterone replacement therapy after primary treatment for prostate cancer. J Urol 2005 feb;183(2):533-6

Arnlov J et al. Endogenous sex hormones and cardiovascular disease incidence in men. Ann Intern Med. 2006 Aug1;145(3):176-84

Bhasin S et al. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2006 Jun;91(6):1995-2010

Caminiti G et al. Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. J Am Coll Cardiol 2009 Sep 1;54(10):919-27

Cardinale M et al. Is testosterone influencing explosive performance? J Strength Cond Res. 2006 Feb;20(1):103-7

Caretta N et al. Erectile dysfunction in aging men: testosterone role in therapeutic protocols. J Endocrinol Invest. 2005; 28(22 Suppl Proceedings):108-11

Davis SR et al. Testosterone enhances estradiol’s effects on postmenopausal bone density and sexuality. Maturitas. 2008 Sept-Oct;61(1-2):17-26

Davison S et al. Phamacokinetics and acute safety of inhaled testosterone in postmenopausal women.  J Clin Pharmacol. 2005 Feb;45(2):177-84

Debing E et al. Endogenous sex hormone levels in postmenopausal women undergoing carotid artery endarterectomy. Eur J Endocrinol. 2007 Jun;156(6):687-93

Dolan SE et al. Effects of weight, body composition, and testosterone on bone mineral density in HIV-infected women. J Acquir Immune Defic Syndr. 2007 Jun1;45(2)161-7

Edinger KL et al. Testosterone’s anti-anxiety and analgesic effects may be due in part to actions of its 5 alpha-reduced metabolites in the hippocampus. Psychoneuroendocrinology. 2005 Jun;30(5):418-30

El-Sakka AI et al. Prostatic specific antigen in patients with hypogonadism: effect of testosterone replacement. J Sex Med. 2005 Mar;2(2):235-40

Endogenous Sex Hormones and Prostate Cancer: A Collaborative Analysis of 18 Prospective Studies Endogenous Hormones and Prostate Cancer Collaborative Group. J Natl Cancer Inst 2008 100:170-183

Fink B et al. The 2nd-4th digit ratio (2D:4D) and neck circumference: implications for risk factors in coronary artery disease. Int J Obes (Lond). 2006 Apr;30

FLoter A et al. Effects of combined estrogen/testosterone therapy on bone and body composition in oophorectomized women. Gynecol Endocrinol. 2005 Mar;20(3):155-60

Gould DC et al. Testosterone replacement therapy for late onset hypogonadism: what is the risk of inducing prostate cancer? Prostate Cancer Prostatic Dis 2006;9(1):14-8

Habib FK et al. Seronoa repens (Permixon) inhibits the 5 alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression. Int J Cancer. 2005 Mar 20;114(2):190-4

Hermans EJ et al. A single administration of testosterone reduces fear-potentiated startle in humans. Biol Psychiatry. 2006 May1;59(9):872-4

Iczkowski, K et al The Dual 5 alpha reductase inhibitor dutatsteride induces atrophic changes and decreases cancer volume in the human prostate. Urology 65:76-82, 2005

Jankowska EA. Circulating estradiol and mortality in men with systolic chronic heart failure. JAMA. 2009 May 13;301(18):1892-901

Khatibi A et al. Could androgens protect middle-aged women from cardiovascular events? A population-based study of Swedish women: The Women’s Health in the Lund Area (WHILA) Study. Climacteric. 2007 Oct;10(5)L386-92

Keogh E. Can a sexually dimorphic index of prenatal hormonal exposure be used to examine cold pressor pain perception in men and women? Eur J Pain. 2006 Apr 4

Khaw KT et al. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men. Circulation. 2007;116:2694-2701

Kupelian V et al. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in non-obese men. J Clin Endocrinol Metabl. 2006 Mar; 91(3):843-50

Lam KS. Serum total and bioavailable testosterone levels, central obesity, and muscle strength changes with aging in health Chinese men. J Am Geriatr Soc. 2008 Jul;67(7):1286-91

Lunenfeld B Endocrinology of the aging male. Minerva Ginecol. 2006 Apr;58(2):153-70

Ly LP et al. Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays. Eur J endocrinol. 2005 Mar;152(3):471-8

Maggio M et al. Correlation between testosterone and the inflammatory marker soluble interleukin-6 (sIL-6r) in older men. J Clin Endocrinol Metabl. 2005 Nov 1

Makinen J et al. Increased carotid atherosclerosis in andropausal middle-aged men. J AmColl Cardiol. 2005 May 17;45(10)

Malkin CJ et al. Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial.  Eur Heart J 2005 Aug 10

Marks LS et al. Effect of testosterone replacement therapy on prostate tissue in men with late=onset hypogonadism: a randomized controlled trial. JAMA 2006 Nov 15; 296(19):2369-71

Moffat SD et al. Long-term measure of free testosterone predict regional cerebral blood flow patterns in elderly men. Neurobiol Aging. 2006 May 11

Morales A. Monitoring androgen replacement therapy: testosterone and prostate safety. J Endocrinol Invest. 2005;28(3 Suppl):122-7

Morgentaler A. Testosterone and Prostate Cancer: An Historical Perspective on a Modern Myth. Eur Urol. 2006 Jul 26

Morgentaler A. Testosterone replacement therapy and prostate risks: where’s the beef? Can J Urol. 2006 Feb;13 Suppl 1:40-3

Morgentaler A. Guideline for Male Testosterone therapy.  A clinician’s perspective. J Clin Endo Metab. 92(2)416-17, 2007

Morgentaler A et al. Two years of testosterone therapy associated with decline in prostate-specific antigen in a man with untreated prostate cancer . J Sex Med. 2009 Feb; 6(2):574-7

Muniyappa R et al. Long-Term Testosterone Supplementation Augments Overnight Growth Hormone Secretion in Health Older Men. Am J Physiol Endocrinol Metab. 2007

Pantuck AJ et al. Phase II Study of Pomegrantate Juice for Men with Risisng Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer . Clin Cancer Res. 2006 Jul 1;12(13):4018-4026

Phillips GB. Is atherosclerotic cardiovascular disease an endocrinological disorder? The estrogen-androgen paradox. J CLin Endocrinol Metab. 2005 May;90(5):2708-11

Sarosdy MF. Testosterone replacement for hypogonadism after treatment of early prostate cancer with brachytherapy. Cancer. 2007 Feb 1;109(3):536-41

Schmidt M et al. Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5 aplapha-reduced androgens. Arthritis Res Ther. 2005;7(5):R938-48

Shakir YA et al. Do sex hormones influence features of the metabolic syndrome in middle-aged women? A population-based study of Swedish womn: The Women’s Health in the Lund Area (WHILA) Study. Fertil Steril. 2007 Jul;88(1):163-71

Shores MM et al. Low serum testosterone and mortality in male veterans. Arch Intern Med. 2006 Aug 14; 116(15):1660-5

Singh AB et al. Pharmacokinetics of a testosterone gel in healthy postmenopausal women. J Clin Endocrinol Metab. 2006 Jan;91(1):136-44

Sinha-Hikim I et al. Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. J Clin Endocrinol Metab. 2006 Aug;91(8):3024-33

Svartberg J. Epidemiology: testosterone and the metabolic syndrome. Int J Impot Res. 2006 Jul 20

Travison TG et al. A population-level decline in serum testosterone levels in American men. J Clin Endocrinol Metabl. 2006 Oct 24

Tsujimura A et al. Treatment with human chorionic gonadotropin for PADAM: preliminary report. Aging Male. 2005 Sep-Dec;8(3-4):175-9

Turhan S et al. The association between androgen levels and premature coronary artery disease in men. Coron Artery Dis. 2007 May;18(3):159-62

Van Geel TA et al. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle mass, muscle strength and bone mineral density in postmenopausal women: a cross-sectional study. Eur J Endocrinol. 2009 Apr;160(4):681-7

Van Honk J et al. Testosterone reduces unconscious fear but not consciously experienced anxiety: implications for the disorders of fear and anxiety. Biol Psychiatry. 2005 Aug1;58(3):218-25

Vigna GB et al. Testosterone replacement, cardiovascular system and risk factors in the aging male. J Endocrinol Invest. 2005; 28(11 Suppl Proceedings):69-74

Yeap BB et al. Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men.  The Health in Men Study. Eur J Endocrinol. 2009 Aug 18

Yeap BB et al. Lower testosterone levels predict incident stroke and transient ischemic attack in older men . J Cin Endocrinol Metab. 2009 Jul;94(7)2353-9

Yeap BB et al. Serum testosterone levels correlate with hemoglobin in middle-aged men and older men. Intern Med J. 2008 Aug 16

Yeap BB et al. Testosterone and ill-health in aging men. Nat Clin Pract Endocrinol Metab. 2009 Feb;5(2):113-21

Yeap BB et al. Are declining testosterone levels a major risk factor for ill-health in aging men? Int J Impot Res. 2009 Jan-Feb;21(1)24-36

Yeap BB et al Healthier lifestyle predicts higher circulating testosterone in older men: The Health in Men Study. Clin Endocrinol (Oxf). 2009 Mar; 70(3):455-63

Yeap BB et al. Luteinizing hormone levels are positively correlated  with plasma amyloid-beta protein levels in elderly men. J Alzheimers Dis. 2008 Jun;14(2):201-8

Yeap BB et al. Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower testosterone in older men: The Health in Men Study. Eur J Endocrinol. 2008 Jun;158(6):785-92

Yeap BB et al. Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry. 2008 Mar;65(3):283-9

Yeap BB et al. Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The Health in Men Study. Clin Endocrinol (Oxf). 2008 Mar;68(3):404-12

Yeap BB et al. In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study. Eur J Endocrinol. 2007 May;156(5):585-9